Sirexatamab(DKN-01)是一种靶向DKK1(dickkopf homolog 1)的人源化单克隆抗体，可用于研究表达DKK1的肿瘤（如晚期食管胃癌）。

YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a reverse-turn agent, inducing apoptosis in CRC cells and displaying strong anti-cancer activities.

ARUK3001185 (Compound 8l) 是选择性的、口服有效的、脑渗透性的 Notum 抑制剂（IC50 = 6.7 nM），适合在啮齿动物疾病模型中口服给药。

Pterostilbene-isothiocyanate是一种 Wnt/β-catenin 信号通路抑制剂。它通过阻断 β-catenin 与 TCF-4 的结合抑制肿瘤增殖和迁移，用于骨肉瘤研究。

ME-143为第二代特异性NADH氧化酶抑制剂，针对结直肠癌细胞中WNT/β-catenin通路展现抑制作用。该化合物在体外及体内显示出广泛的抗癌活性。

4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatment of brain diseases.

β-Cateninmodulator-4 (compound IIa-92) 为恶唑与噻唑类化合物，兼具高效性与选择性，作为β-Catenin调节剂。

Tabituximab barzuxetan (OTSA101-DTPA-90Y) 是一种放射免疫偶联物，由靶向FZD-10 (OTSA-101)的人源化单克隆抗体组成，并用钇 90 标记。Tabituximab barzuxetan 具有抗肿瘤活性。Tabituximab barzuxetan 可用于滑膜肉瘤的研究。

YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks.References1. Obianom, O.N., Ai, Y., Li, Y., et al. Triazole-based inhibitors of the Wnt/β-catenin signaling pathway improve glucose and lipid metabolism in diet-induced obese mice. J. Med. Chem. 62(2), 727-741 (2019). YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin i