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GW4869
目录号:SY-128349
GW4869 (GW69A) 是一种中性鞘磷脂酶 N-SMase 的抑制剂 (IC50=1 μM),具有选择性和非竞争性。GW4869 也可以抑制外泌体合成/释放,常用于外泌体相关研究。该化合物通常配制成混悬液进行实验。
¥345.00
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EMD638683 S-Form
目录号:SY-128830
EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 S-Form is the S-form of EMD638683.
¥3519.00
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α-Glucosylrutin
目录号:SY-128679
α-Glucosylrutin 是一种具备清除自由基活性的有效抗氧化剂。由于其在表皮生物利用度较高,常用于研究皮肤衰老。
¥322.00
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DPTIP
目录号:SY-128379
DPTIP 是一种有效的中性鞘磷脂酶 2 抑制剂,IC50 值为 30 nM。
¥1758.00
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Pyrrophenone
目录号:SY-128419
The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins (PGs) and leukotrienes (LTs). Pyrrophenone inhibits cPLA2α with an IC50 of 4.2 nM in enzyme assays and potently blocks the release of AA and the production of PGE2 and LTC4 in cells (IC50 = 24, 25, and 14 nM, respectively). Its action is reversible and selective, as pyrrophenone inhibits the secretory type IB and IIA PLA2s with more than a hundred-fold less potency. Pyrrophenone has also been shown to inhibit calcium ionophore (A23187)-stimulated AA release from monocytic cells, interleukin-1-induced PGE2 synthesis in mesangial cells, and the production of PGE2, LTs, and platelet-activating factor by human neutrophils, always with maximal inhibition at concentrations below 1 μM.
¥2760.00
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L-778123 hydrochloride
目录号:SY-128883
L-778123 hydrochloride 是一种FPTase 和GGPTase-I 双重抑制剂,IC50分别为2 nM 和 98 nM。
¥342.00
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RORγt agonist 3
目录号:SY-128537
RORγt agonist 3 是 RORγt 的有效激动剂。RORγt agonist 3 能够促使 Th17 细胞分化,增加促炎细胞因子水平,进而提高淋巴细胞的细胞毒性。RORγt agonist 3 能够阻碍调节性 T 细胞的产生,并免疫反应产生抑制作用。
¥1232.00
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BMS453
目录号:SY-128797
BMS453 (BMS-189453) 是一种合成类维生素 A,是一种 RARβ激动剂,也是一种 RARα/RARγ拮抗剂。它主要通过诱导活性 TGFβ 来抑制乳腺细胞生长。
¥495.00
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CCR1/5/8 activator 1
目录号:SY-128404
CCR1/5/8 activator 1 是胞质磷脂酶 A 抑制剂,具有抗真菌活性。
¥150.00
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