BRD9500 是一种具有口服活性的磷酸二酯酶 3 (PDE3) 抑制剂，对PDE3A 和PDE3B 的IC50分别为 10 和 27 nM。BRD9500 在黑色素瘤细胞系 SK-MEL-3 癌症异种移植模型中具有活性。

TDP1 Inhibitor-1 is a potent inhibitor of Tyrosyl-DNA Phosphodiesterase 1 (TDP1) (IC50 of 7 μM).

Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition of the transcriptional activity of NF-κB. Braylin is also a phosphodiesterase-4 inhibitor, it could represent an ideal prototype of glucocorticoid receptor ligand, able to induce synergic immunomodulatory effects.

LEO-32731 is a bioactive chemical.

PDE7-IN-2 是磷酸二酯酶 7 (IC50 = 2.1 µM) 的抑制剂，可用于帕金森病研究。

Roflumilast Impurity E is an impurity of Roflumilast, which acts as a selective and long-acting enzyme PDE-4 inhibitor (IC50 value of 0.8 nM).

TPN729MA (TPN729 maleate) 是一种选择性 phosphodiesterasetype 5 (PDE5) 抑制剂，IC50值为 2.28 nM。TPN729MA 影响勃起功能，可用于勃起功能障碍的研究。

PDE2/PDE10-IN-1 is a inhibitor of phosphodiesterase 2 (PDE2) and PDE10(IC50s of 29 and 480 nM, respectively).

4'-Methoxyisoagarotetrol 是一种色素衍生物，表现出中等强度的PDE3A抑制活性，其半抑制浓度（IC50）为54 μM。