Rebeccamycin

目录号：SY-100628

Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.

¥17250.00

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(R)-Exatecan Intermediate 1

目录号：SY-100629

(R)-Exatecan Intermediate 1 为 Exatecan Intermediate 1 的异构体,属于Exatecan的中间体之一.Exatecan (compound 6) 作为一种喜树碱类的抗癌药物,其机制是通过与DNA相互作用,进而干扰肿瘤细胞的增殖与分裂,抑制癌症生长.该药物主要用于研究卵巢癌、肺癌和乳腺癌等多种癌症.

¥425.00

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Exatecan Intermediate 5

目录号：SY-100630

Exatecan Intermediate 5 作为Exatecan的中间体,其应用广泛.Exatecan (DX-8951),一个有效的DNA拓扑异构酶I (topoisomerase I) 抑制剂,具IC50为2.2 μM (0.975 μg/mL),主要用于癌症治疗研究.此外,Exatecan Intermediate 5 还关键于抗体-药物偶联物 (Antibody-Drug Conjugates (ADCs)) 的合成过程.

¥7590.00

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Tubulysin A

目录号：SY-100631

Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angiogenic.

¥4312.00

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DC0-NH2

目录号：SY-100632

The cytotoxicity of DC0-NH2 is 1000 times that of commonly used anti-cancer drugs (such as doxorubicin). It is the effect part of ADC. It is a simplified simulation of DC1 and has better stability. DC0-NH2 can bind to the small groove of DNA, and then ade

¥2530.00

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NH2-methylpropanamide-Exatecan TFA

目录号：SY-100633

NH2-methylpropanamide-Exatecan (TFA) 为对异丁酰胺进行修饰的Exatecan，属于ADC毒素（ADC Cytotoxin），应用于ADC合成中。该化合物作为DNA拓扑异构酶I（topoisomerase I）抑制剂，具有2.2 μM（0.975 μg/mL）的IC50，适用于癌症研究。

¥5060.00

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Tomaymycin DM

目录号：SY-100634

Tomaymycin DM，一种Tomaymycin衍生的DNA烷化剂，作为肿瘤靶向抗体偶联活性分子(ADCs)有效载荷，是PBD单体。

¥1805.00

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β-Amanitin

目录号：SY-100635

β-Amanitin, a cyclic peptide toxin found in the poisonous Amanita phalloides mushroom, inhibits eukaryotic RNA polymerase II and III, thereby disrupting protein synthesis.

¥6773.00

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SJG-136

目录号：SY-100636

SJG-136 is a DNA cross-linking agent (XL50: 45 nM for pBR322 DNA).

¥2576.00

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