1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodia rutaecarpa (Juss.) Benth. 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of type B MAO (MAO-B) activity with the IC(50) value of 15.3 microM using a substrate kynuramine, but does not inhibit type A MAO (MAO-A) activity.It can mitigate high phosphate-induced human aortic valve interstitial cells (HAVICs) calcification by inhibiting phosphate cotransporter (PiT-1) gene expression. It also shows moderate antiangiogenic activity against human tumor cells.

Oglemilast (GRC 3886) 是一种具有口服活性磷酸二酯酶 4 (PDE4) 抑制剂，对 PDE4D3 的 IC50 为 0.5 nM。Oglemilast 在体外和体内抑制肺细胞浸润，包括嗜酸性粒细胞增多和嗜中性粒细胞减少。Oglemilast 具有应用于炎症性气道疾病的潜力。

Thioquinapiperifil dihydrochloride 是一种磷酸二酯酶(PDE-5)抑制剂（IC50： 0.074 nM），具有有效性、选择性和非竞争性，可用于研究性成熟。

Trequinsin hydrochloride (HL 725) 是一种高效磷酸二酯酶 (PDE)抑制剂，也是血小板聚集的抑制剂，是新型抗高血压血管扩张剂，可用于研究心血管疾病。

Pumafentrine（BY 343） 是 PDE3/PDE4双重抑制剂，可降低小鼠实验性结肠炎的临床评分和 TNF 表达。

Minaprine 是一种单胺氧化酶 MAO-A 可逆性抑制剂，对乙酰胆碱酯酶有微弱抑制，是一种抗抑郁类化合物。

Nialamide (Nialamid) 是非选择性的，不可逆的单胺氧化酶抑制剂，是一种抗抑郁药。

Moclobemide (Ro111163) 是可逆的、可透过血脑屏障的单胺氧化酶 (MAO-A) 抑制剂，能够抑制 hMAO-A (IC50=6.061 μM)。它上调慢性应激小鼠海马祖细胞的增殖。

ABC34 is an inactive control probe for JJH260 , the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). ABC34 demonstrates an IC50 value greater than 25 μM for the inhibition of 9-PAHSA but is more potent in blocking the serine hydrolase ABHD6 and the palmitoyl-protein hydrolase PPT1, which are both off-targets of JJH260.