TDP1 Inhibitor-2 是一种 TDP1 (酪氨酰 -DNA 磷酸二酯酶 1) 的有效抑制剂 (IC50: 99 nM)。TDP1 Inhibitor-2 对 SCAN1 (脊髓小脑共济失调综合征伴轴突神经病变) 具有抑制作用 (IC50: 3.5 μM)。

PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11. PF-05085727 is an effective, selective and brain penetrant inhibitor of cGMP-dependent PDE2A (IC50=2 nM) .

Mangostanol is an acetylcholinesterase (AChE) selective inhibitor.Mangostanol has anti-cancer activity, it shows significant activities against the CEM-SS cell line, with IC50 values of 9.6 microg/ml.

BRD9500 是一种具有口服活性的磷酸二酯酶 3 (PDE3) 抑制剂，对PDE3A 和PDE3B 的IC50分别为 10 和 27 nM。BRD9500 在黑色素瘤细胞系 SK-MEL-3 癌症异种移植模型中具有活性。

TDP1 Inhibitor-1 is a potent inhibitor of Tyrosyl-DNA Phosphodiesterase 1 (TDP1) (IC50 of 7 μM).

Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition of the transcriptional activity of NF-κB. Braylin is also a phosphodiesterase-4 inhibitor, it could represent an ideal prototype of glucocorticoid receptor ligand, able to induce synergic immunomodulatory effects.