GNF-1331 is a potent, selective, and orally bioavailable porcupine inhibitor (IC50 = 12 nM). Blocking abnormal Wnt signaling is an attractive treatment for a variety of cancers.

TWS-119是一种强效 GSK-3β 抑制剂，可激活 Wnt/β-catenin 信号通路。它能诱导神经元分化，增强 T 细胞抗肿瘤活性，并在缺血性卒中模型中保护血脑屏障。

A3051, is a robust and orally active inhibitor of CXXC5-DVL with an IC 50 of 63.06 nM. Its applications include research into phenotypes associated with obesity, diabetes, and NASH that are induced by high fat diet (HFD) and methionine-choline deficient diet (MCD).

16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an interaction with the Wnt pathway.

UU-T01 是 β-Catenin/T-cell factor 4 蛋白互作 (β-catenin/Tcf PPI) 的选择性抑制剂，Ki 值为 3.14 µM。UU-T01 与β-catenin 直接结合，KD 值为 0.531 µM。

Ganodermanontriol 是从 GL 中提取得到的纯化三萜化合物，能够抑制结肠癌细胞 HCT-116 和 HT-29 的增殖，同时不显著影响细胞活性，并呈剂量依赖性抑制 β-catenin 转录活性及 cyclin D1 表达，减少 Cdk-4 与 PCNA，同时增加 HT-29 细胞中 E-cadherin 与 β-catenin 累积。在 HT-29 异种移植小鼠模型中，其可显著抑制肿瘤生长且无明显毒性，表明其在结直肠癌化疗研究中具有良好应用前景。

β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of colorectal cancer cells SW480 and HCT116, with IC50 values of 20 μM and 31 μM, respectively.

C-Peptide 1 (rat)是一种从胰岛素原中分离出来的多肽。C-Peptide是β-catenin/GSK-3β激活剂，还能够影响Na/K-ATPase的活性，调节细胞凋亡，能够改善糖尿病神经病变。

NSC-668036 is an inhibitor of Dishevelled (Dvl) protein, a key protein in wnt signaling.