TNIK-IN-1 (Compound 1) 是一种高效的 Traf2 和 Nck 相互作用激酶 (TNIK) 抑制剂，其 IC50 值为 65 nM。TNIK 是 Wnt/beta-catenin 信号通路中的关键效应分子，对于维持肿瘤干细胞的特性和促进细胞增殖至关重要。作为一种基于 4-苯基-2-苯氨基吡啶骨架的先导化合物，TNIK-IN-1 展现出显著的抗肿瘤活性，通过阻断 TNIK 的激酶功能来抑制致癌信号的传递，是研究 Wnt 相关恶性肿瘤的有力工具 。

Sirexatamab(DKN-01)是一种靶向DKK1(dickkopf homolog 1)的人源化单克隆抗体，可用于研究表达DKK1的肿瘤（如晚期食管胃癌）。

YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a reverse-turn agent, inducing apoptosis in CRC cells and displaying strong anti-cancer activities.

ARUK3001185 (Compound 8l) 是选择性的、口服有效的、脑渗透性的 Notum 抑制剂（IC50 = 6.7 nM），适合在啮齿动物疾病模型中口服给药。

Notum-IN-1 是一种口服有效的、选择性、脑渗透性的Notum 抑制剂。Notum-IN-1 在小鼠体内阻断Wnt 信号。

β-catenin peptide,(βCATp) is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes.

ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a K i value of 0.76 μM and an IC 50 value of 0.87 μM.

NC043 is an inhibitor of Wnt/β-catenin signaling, it forms a covalent bond with the Cys-516 residue of CARF.

OM-153 是 tankyrase 的有效抑制剂，能够作用于 tankyrase 1 (IC50: 13 nM) 和 tankyrase 2 (IC50: 2 nM)，且对 COLO 320DM 中的 WNT/β-连环蛋白信号传导和增殖具有抑制作用。