Tabituximab barzuxetan (OTSA101-DTPA-90Y) 是一种放射免疫偶联物，由靶向FZD-10 (OTSA-101)的人源化单克隆抗体组成，并用钇 90 标记。Tabituximab barzuxetan 具有抗肿瘤活性。Tabituximab barzuxetan 可用于滑膜肉瘤的研究。

YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks.References1. Obianom, O.N., Ai, Y., Li, Y., et al. Triazole-based inhibitors of the Wnt/β-catenin signaling pathway improve glucose and lipid metabolism in diet-induced obese mice. J. Med. Chem. 62(2), 727-741 (2019). YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin i

Gypenoside LI是一种具有抗癌活性的天然产物，能够产生ROS，下调procaspase-8和MMP-2/9，抑制Wnt/β-catenin，引起细胞周期阻滞和凋亡。

inhibitor of cancer stem cells

YW2065 has excellent anti-colorectal cancer effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity.

Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.

9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as well as SV probably through interfering with Ca2+ mobilization.9-Hydroxycanthin-6-one inhibits Wnt signaling through the activation of GSK3β independent of CK1α.

WAY 316606 hydrochloride是一种sFRP-1分泌蛋白抑制剂，兼作分泌性糖蛋白Wnt的拮抗剂。在FP结合检测中，其对sFRP-1的IC50为0.5 μM。

WNTinib (APS-8-100-2) 作为一种多激酶抑制剂，专门针对具有β-catenin(CTNNB1)突变的肝细胞癌(HCC)展示出高选择性。该化合物通过阻断KIT/MAPK及其下游EZH2的激活，进而抑制致癌Wnt信号传递。