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Pyrrophenone
目录号:SY-128419
The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins (PGs) and leukotrienes (LTs). Pyrrophenone inhibits cPLA2α with an IC50 of 4.2 nM in enzyme assays and potently blocks the release of AA and the production of PGE2 and LTC4 in cells (IC50 = 24, 25, and 14 nM, respectively). Its action is reversible and selective, as pyrrophenone inhibits the secretory type IB and IIA PLA2s with more than a hundred-fold less potency. Pyrrophenone has also been shown to inhibit calcium ionophore (A23187)-stimulated AA release from monocytic cells, interleukin-1-induced PGE2 synthesis in mesangial cells, and the production of PGE2, LTs, and platelet-activating factor by human neutrophils, always with maximal inhibition at concentrations below 1 μM.
¥2760.00
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Lapaquistat acetate
目录号:SY-128875
Lapaquistat acetate (TAK-475) 是一种角鲨烯合酶抑制剂,具有潜在的抗炎活性。Lapaquistat acetate 减弱他汀类药物诱导的人骨骼肌细胞中的细胞毒性,保护豚鼠免受塞利伐他汀诱导的肌毒性,可用于研究高胆固醇血症和甲羟戊酸激酶缺乏症。
¥1140.00
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UDP-GlcNAz disodium
目录号:SY-128920
Uridine diphosphate glucuronic acid (UDP-GlcA) trisodium 是一种在 UDP-葡萄糖脱氢酶催化过程中形成的辅助因子。它含有 Azide 基团,能够与含有 Alkyne 基团的分子进行铜催化的叠氮-炔环加成反应(CuAAc)。此外,它也可以与具有 DBCO 或 BCN 基团的分子进行环张力促进的炔-叠氮环加成反应 (SPAAC)。
¥1208.00
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Acivicin
目录号:SY-128910
Acivicin (AT-125) 是一种由猪链霉菌产生的氯化氨基酸抗生素,是一种可以透过血脑屏障的 γ-谷氨酰转肽酶 (GGT) 抑制剂,具有抗癌和抗寄生虫活性,可用于研究内脏利什曼病。
¥2650.00
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Luciferase activator-1
目录号:SY-128697
Luciferase activator-1 (Compound D2) 作为荧光素酶的激活剂,在浓度为 50 nM 时能使荧光素酶活性提升至1.04倍。
询价
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1,3-Diphenylisobenzofuran
目录号:SY-128591
1,3-Diphenylisobenzofuran (DPBF) 是一种荧光探针,对单线态氧(1O2) 的具有高特异性,可形成内过氧化物并分解成 1,2-dibenzoylbenzene,可用于活性氧生成的检测。
¥342.00
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24R-Calcipotriol
目录号:SY-128984
24R-Calcipotriol (PRI 2202) is an impurity of Calcipotriol, a ligand of VDR-like receptors.
¥6325.00
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6-Deoxyjacareubin
目录号:SY-128667
6-Deoxyjacareubin 具有有效的抗氧化和抗真菌活性。 6-Deoxyjacareubin 抑制血小板活化因子 (PAF) 受体,IC50 为 29.0 microM,可用于天然 PAF 受体拮抗剂的研究。
¥4738.00
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1alpha, 25-Dihydroxy VD2-D6
目录号:SY-128991
1alpha, 25-Dihydroxy VD2-D6 is a deuterated form of vitamin D.
¥26795.00
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