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DSPE-N3
目录号:SY-127385
DSPE-N3 是一种脂质。DSPE-N3 可用于多种生化研究。
¥321.00
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ML202
目录号:SY-128164
ML202作为一种变构激活剂,针对人丙酮酸激酶M2 (hPK-M2)展现出高度特异性,能够影响磷酸烯醇丙酮酸(PEP)结合的协同性,而对二磷酸腺苷(ADP)的结合几乎无影响。
¥868.00
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Benserazide hydrochloride
目录号:SY-128148
Benserazide hydrochloride (Ro 4-4602) 是一种芳香族 L-氨基酸脱羧酶(AADC)的抑制剂,常用于帕金森病。
¥5175.00
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PF-04449613
目录号:SY-128132
PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50= 22 nM).1It is selective for PDE9A over PDE1C (IC50= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 μM but does inhibit the human dopamine transporter (DAT; Ki= 293 nM). PF-04449613 (0.1-100 mg/kg, s.c.) increases cerebrospinal fluid (CSF) levels of cyclic GMP (cGMP) in rats. Subcutaneous administration of PF-04449613 (10 mg/kg) increases the rate of dendritic spine formation and elimination in mouse primary motor cortex pyramidal neuronsin vivo.2It increases the average running speed of mice in an accelerating rotarod task, indicating improved motor learning, at the same dose. 1.Claffey, M.M., Helal, C.J., Verhoest, P.R., et al.Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitorsJ. Med. Chem.55(21)9055-90
¥1955.00
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PF-8380 hydrochloride
目录号:SY-128116
PF-8380 hydrochloride 是一种有效的autotaxin 抑制剂,体外酶实验和人类全血细胞实验中,IC50分别为 2.8 nM 和 101 nM。
¥8706.00
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Phosphodiesterase II
目录号:SY-128100
PhosphodiesteraseII,即磷酸二酯酶 2,主要参与水解重要的第二信使环磷酸腺苷 (cAMP) 和环磷酸鸟苷 (cGMP),常用于生化研究。PhosphodiesteraseII 表达于多种组织,如肾上腺髓质、脑、心脏、血小板、巨噬细胞和内皮细胞,可参与调节许多不同的细胞内过程。
¥1483.00
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Ipenoxazone
目录号:SY-128068
Ipenoxazone is an effective and centrally acting muscle relaxant.
¥2576.00
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TDP1 Inhibitor-1
目录号:SY-128052
TDP1 Inhibitor-1 is a potent inhibitor of Tyrosyl-DNA Phosphodiesterase 1 (TDP1) (IC50 of 7 μM).
¥9016.00
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Sp-Cyclic AMPS (sodium salt)
目录号:SY-128036
Sp-cAMPS sodium salt 作为 cAMP 类似物,是一种依赖 cAMP 的PKA I 和PKA II 的有效激活剂。Sp-cAMPS sodium salt 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂,Ki 为 47.6 μM。Sp-cAMPS sodium salt 结合PDE10 GAF 结构域,EC50为 40 μM 。
¥990.00
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