Epiandrosterone (EpiA) 是一种人内源性代谢物和类固醇激素, 具有弱雄激素特性。

Lubabegron, also known as LY591281; LY488756 fumarate, is a veterinary drug used to reduce ammonia emissions from animals and their waste. Ammonia emissions are a concern in agricultural production because of detrimental effects on the environment, human health, and animal health. Lubabegron was approved by the U.S. Food and Drug Administration in 2018 for use in feedlot cattle. Lubabegron is a beta-adrenergic receptor agonist that has the effect of increasing the breakdown of fats and increasing energy expenditure in cells.

steroidal androgen receptor agonist

ARD-1676为口服有效的雄激素受体(AR) PROTAC降解剂，结合了AR配体与cereblon配体。该化合物能降解体内外的AR，并在小鼠异种移植VCaP肿瘤模型中显示抑制肿瘤生长的活性。

JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM. JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2. JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.

MK-4541是一种选择性、口服有效的雄激素受体(AR)调节剂，能作为拮抗剂抑制5α-还原酶，从而抑制AR阳性前列腺癌细胞的增殖并诱导凋亡(apoptosis)。此外，MK-4541在异种移植小鼠模型中显著抑制R3327-G前列腺肿瘤的生长。