6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans., The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.

5α-Tetrahydrocorticosterone (5α-HB) 是一种内源性类固醇, 作为糖皮质激素受体 (glucocorticoid receptor) (GR) 的激动剂，同时是 Corticosterone 的代谢产物。这种化合物在体内是有效的局部抗炎剂。5α-Tetrahydrocorticosterone 通过降低大鼠肝细胞中代谢物与糖皮质激素受体-皮质酮及其 5α-还原代谢物的结合，显示出Kd值为 268 nM。在炎症性皮肤疾病的研究中，5α-Tetrahydrocorticosterone 具有重要应用。

LEO 134310 是一种选择性非甾体糖皮质激素受体 (GR) 激动剂，优化用于局部治疗。LEO 134310 在 GR 结合试验中显示出高亲和力(EC50为 14 nM)。LEO 134310 可用于皮肤病。

ACTH (6-24) (human)（腎上腺皮質激素（6-24））是腎上腺皮質激素的片段。該化合物作為ACTH (1-39) 和 ACTH (5-24) 引起的類固醇生成的競爭性抑制劑，具有相應的Kd值分別為13.4和3.4nM。此外，ACTH (6-24) (human) 能夠抑制 hPTH 1-34 所誘導的皮質酮產生以及cAMP的累積。

AL-438 is a non-steroidal selective glucocorticoid receptor modulator.

PF-0251802 HCl is a bio-active chemical.