PF-06747711 is an effective and selective retinoic acid receptor-related orphan C2 inverse agonist (IC50: 4.1 nM). PF-06747711 also has anti-skin inflammatory activity.

SPR inhibitor 3是一类用于抑制Sepiapterin reductase活性的小分子化合物，可阻断四氢生物蝶呤（BH4）的生物合成途径，影响一氧化氮合酶及单胺类神经递质的生成。

7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human na ve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate and ionomycin .

TMP778 is an effective and selective RORγt inverse agonist (IC50: 7 nM in FRET assay).

RORγt modulator 5 是一种 RORγt 调节剂，Ki 值 <100 nM。RORγt modulator 5 可用于研究 RORy 介导的炎症、代谢、自身免疫和其他疾病。

L 012 sodium salt 是一种 luminol 类似物，是一种广泛使用的活性氧和活性氮的化学发光(CL)探针 的化学发光 (CL) 探针。L 012 sodium salt 广泛用于检测 NADPH 氧化酶 (Nox) 衍生的超氧化物 (O2•−) ，用于发现 Nox 抑制剂。