urotensin II (UT) receptor antagonist

GPR52 agonist-1 是一种有效的、口服具有活力的、能够透过血脑屏障的 GPR52 激动剂 (pEC50:7.53)，具有抗精神病作用。GPR52 agonist-1 可以直接与 GPR52 相互作用，进而影响 cAMP 积累。GPR52 agonist-1 可以明显抑制甲基苯丙胺 (Methamphetamine) 诱导的小鼠多动行为。

GPR120 modulator 2 is useful for modulating GPR120.

Urotensin II (114-124), human, is an 11-amino acid residue peptide that exhibits strong vasoconstrictor activity and acts as an agonist for the orphan receptor GPR14.

Urotensin-II (UT) receptor pure antagonist (pEC50 = 7.24). Displays no agonist activity unlike other U-II/URP analogs. Inhibits the action of U-II in the rat aorta ring assay.

GSK706 is a novel effective agonist of the GPR119.

Firuglipel is an orally available and selective agonist of GPR119.

FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assays, displays positive allosteric modulation of FFA-induced Gi signaling and negative allosteric modulation of FFA-induced Gq/G11 signaling. Inhibits lipolytic effect of isoproterenol (pEC50 = 5.03) and induces migration of human neutrophils in vitro. Bolognini et al (2016) A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias. J.Biol.Chem. 291 18915 PMID:27385588 |Sergeev et al (2017) A single extracellular amino acid in free fatty acid receptor 2 defines antagonist species selectivity and G protein selection bias. Sci.Rep. 7 13741 PMID:29061999

FFA3 agonist 1为一种FFA3（游离脂肪酸受体 3）激动剂，功能为通过激活FFA3以调节肠道微生物群的健康效应。