Lp-PLA2-IN-1 (Lp-PLA2 inhibitor 1) 是脂蛋白相关磷脂酶 A2(Lp-PLA2) 抑制剂。它有潜力用于动脉粥样硬化、阿尔茨海默氏病的研究。

Vinaxanthone (SM-345431) 是一种从青霉菌中提取的小分子化合物，是一种具有选择性和有效性的 semaphorin3A、phospholipase C (PLC) 和 FabI 抑制剂，抑制semaphorin3A 和 FabI。Vinaxanthone 具有抗菌活性，阻止细胞内脂肪酸合成，抑制金黄色葡萄球菌的生长。

MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. IC50 value: 1 nM (hSCD1) Target: SCD1 in vitro: MK-8245, a phenoxy piperidine isoxazole derivative, has been identified as a potent and liver-specific SCD inhibitor. It contains a tetrazole acetic acid moiety, which is the key molecule for OATPs recognition and liver-targeting. MK-8245 displays similar potencies against human, rat and mouse SCD1 with IC50 values of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1. MK-8245 exhibits a significant SCD inhibition in the rat hepatocyte assay which contains functional, active OATPs with IC50 of 68 nM, while being only weakly active in the HepG2 cell assay which is devoid of active OATPs with IC50 of ~1 μM. MK-8245 displays highly selective activity for the Δ-5 and Δ-6 desaturases (i.e., >100000 μM vs rat and human Δ5

GK187 是一种具有选择性和高效性的 Group VIA 钙非依赖性磷脂酶A2 (GVIA iPLA2) 抑制剂，可用于研究神经系统疾病。

Tipifarnib S enantiomer ((S)-(-)-R-115777) 是Tipifarnib 的 S 型对映体，它比 Tipifarnib 特性低。其中 Tipifarnib 是farnesyltransferase 高效特异性抑制剂，IC50=0.6 nM。

N-(p-amylcinnamoyl) Anthranilic Acid (ACA) 是一种广谱磷脂酶 A2(PLA2) 抑制剂，也是TRP channel 的阻滞剂。ACA 也可逆的抑制钙离子激活氯通道 (calcium-activated chloride channels) ，在心律失常方面具有研究的潜力。

YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.

Entacapone acid (AG 1290) 是一种选择性和可逆的儿茶酚-O-甲基转移酶 (COMT) 抑制剂。

7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human na ve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate and ionomycin .