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三叶新科每月上新,持续为科研人员提供新颖性研究工具,助力科研创新与突破。
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Osemitamab
目录号:SY-109521
Osemitamab(TST001)是一种针对claudin-18.2的人源化单克隆抗体,由人鼠嵌合体TST001的γ-1链与κ链的二聚体构成,具有对NK细胞介导的肿瘤杀伤活性,可用于胃/胃食管结合部腺癌,PDAC和肺癌。
¥667.00
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Fuzapladib
目录号:SY-109716
Fuzapladib (IS-741) (IS-741)是一种磷脂酶A2抑制剂,可以抑制细胞粘附分子Mac-1的表达。fuzpladib 阻断炎症细胞表面表达的粘附分子(integrin)的激活,阻止炎症细胞粘附血管内皮细胞和浸润组织,控制胰腺炎的恶化。
¥770.00
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Gantofiban
目录号:SY-109730
Gantofiban是一种糖蛋白 IIb/IIIa(GP IIb/IIIa)拮抗剂,可用于治疗心血管疾病,可用于研究血栓形成。
¥918.00
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Cyclo(RADfK)
目录号:SY-109738
Cyclo(RADfK) 是选择性 α(v)β(3) 整合素配体,广泛用于新血管生成的研究、治疗和诊断。它是 cyclo (-RGDfK-) 的阴性对照, RGD 肽。 RGD 肽是细胞粘附的调节剂,并被整合素家族的几个成员识别。
¥920.00
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6-O-Caffeoylarbutin
目录号:SY-109328
6-O-Caffeoylarbutin(Robustaside B)是一种抗氧化的天然产物,能够诱导线粒体膜通透性转变,能够调节SIRT1/PI3K/AKT/NF-κB通路,改善小鼠的肝损伤和缺血性脑卒中症状。
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α-Linolenic Acid (sodium salt)
目录号:SY-109285
α-Linolenic acid (ALA) is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.
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CC-90005
目录号:SY-110087
CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by IL-2 expression[1]. CC-90005 shows the exquisite selectivity of CC-90005, with IC50s for all other family members of >3 μM[1].CC-90005 is a moderate inhibitor of both CYP2C9 (IC50=8 μM) and CYP2C19 (IC50=5.9 μM) in human liver microsomes[1].CC-90005 inhibits IL-2 expression in LRS_WBC human PBMCs, with an IC50 of 0.15 μM[1].CC-90005 (1-10 μM; 24 h) inhibits T cell proliferation in PBMCs by 51% at 1 μM and 88% at 3 μM[1]. CC-90005 (3-30 mg/kg; p.o. twice daily for 4 days) significantly reduces the popliteal lymph node (PLN) size in a model of chronic T cell activation[1].CC-90005 (100 mg/kg; a single p.o.) significantly inhibits plasma and spleen IL-2 release by 51 and 54%, respectively[1].CC-90005 exhibits reasonable oral bioavailability (66 and 46%) and Cmax (1.18 and 1
¥3949.00
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DOTA-cyclo(RGDfK)
目录号:SY-109726
DOTA-cyclo(RGDfK) 是一种和DOTA类螯合剂多肽,由多肽交联剂DOTA和环状多肽RGDFK构成二聚体,优先靶向肿瘤细胞膜上表达的αvβ3整合素受体,可制备放射性核素偶联物(RDC)并用于癌症诊断和治疗。
¥943.00
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6'-Sialyllactose Sodium Salt
目录号:SY-109193
6'-Sialyllactose Sodium Salt (6'-N-Acetylneuraminyl-D-lactose sodium salt)是一种存在于母乳中的低聚糖,对 LPS 诱导的 ALI 具有保护作用,通过抑制 STAT1 和 NF-κB 信号通路来减轻 LPS 诱导的肺损伤。
¥920.00
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