Hydroxy celecoxib, an inactive metabolite of celecoxib, is synthesized through the metabolism of celecoxib by cytochrome P450 (CYP) isoforms CYP2C9, CYP3A4, and CYP2D6 in human liver microsomes.

3-Phenyltoxoflavin (Phenyltoxoflavin) 是一种 HSP90 (Kd = 585 nM) 抑制剂，具有抗癌活性。

N-Desmethyltamoxifen, the principal metabolite of tamoxifen in humans, serves as an efficacious modulator of ceramide metabolism within human AML cells by inhibiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation. Although it demonstrates weak antiestrogenic properties, it acts as a protein kinase C (PKC) inhibitor with a potency ten times greater than that of tamoxifen.

Crosstide is a peptide analog of glycogen synthase kinase-3 (GSK-3) and serves as a natural substrate for Akt/PKB.

DynaminIN-1 是一种有效的dynamin 抑制剂，IC50值为 1.0 µM。

Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride) 是一种从植物中提取的花青素，是一种 NO和 H274Y 突变的抑制剂，对流感神经氨酸酶具有抑制作用。Cyanidin 3-sambubioside chloride 具有抗氧化，抗血管生成和抗病毒活性，抑制血管紧张素转换酶 (ACE) 的活性，可用于研究病毒感染和心血管疾病。

Isosativan是一种发现于Trifolium hybridum的天然产物，能够激活糖尿病大鼠mTORC2/AKT通路，抑制肌肉萎缩基因Atrogin-1和MuRF1。

2',4'-DIHYDROXYCHALCONE (2',4'-DHC) 作为具有 Hsp90 抑制和抗真菌作用的化合物

Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) 是蛋白激酶 C 特异性抑制剂，通过抑制 PKC 和 PI3-激酶途径诱导实体瘤细胞自噬，诱导癌细胞死亡。Safingol hydrochloride 抑制 PKC 和 PI3k。